摘要
目的:观察罗格列酮(RSG)对大鼠急性心肌缺血再灌注(I-R)损伤心肌梗死面积、心律失常发生率和心肌病理学改变的影响。方法:结扎大鼠左冠状动脉前降支30 min、再灌注120 min建立大鼠心肌I-R损伤模型,将大鼠随机分为I-R损伤模型组、RSG高剂量(6 mg.kg-1)、低剂量(3 mg.kg-1)组和假手术组,灌胃给药1周后行I-R损伤手术,观察心肌梗死面积、心律失常发生次数和类型、心肌组织学改变和心肌细胞超微结构的变化。结果:与模型组比较,RSG高剂量组心肌梗死面积与左心室面积百分率(IS/LV%,29.3±4.9vs37.6±3.2)以及心肌梗死面积与危险区面积比值(IS/AAR%,76.1±9.6vs93.5±7.4)减少(P<0.05或P<0.01);RSG高量组心律失常评分(2.6±0.4)低于I-R损伤模型组(4.2±0.6)(P<0.05)。RSG组心肌病理组织学和心肌细胞超微结构损伤轻于I-R损伤模型组。结论:RSG可通过减少I-R损伤大鼠心肌梗死面积、减少恶性心律失常的发生及改善病理组织学损伤而起到对大鼠心肌I-R损伤的保护作用。
Objective To observe the effects of rosiglitazone （RSG） on myocardial infarct size （IS）, incidence rate of arrhythmias and the pathohistological changes in rat model of acute myocardial ischemia-reperfusion （I-R） injury. Methods The rat myocardial I-R injury model was induced by ligating left anterior descending branch of coronary artery for 30 min and reperfusing for 120 rain. Wistar rats were randomly divided into four groups： I-R group, RSG groups with the doses of 3 and 6 mg· k^- 1 , and sham-operation group. IS, times and types of arrhythmia, pathohistological changes of myocardium tissue and changes of myocardial cell ultrastructure were observed. Results Compared with I-R group, RSG decreased the ratio of IS/LV% （29.3±4.9 vs 37.6±3.2, P〈0.05） and the rate of IS/AAR% （76.1±9.6 vs 93.5±7.4, P〈0.05）, reduced the score of arrhythmias （2.6±0.4 vs 46.2 ± 0.6, P〈0.05）, the injuries of pathohistology of myocardium and myocardial cell uhrastructure in RSG group were better that those in I-R group. Conclusion RSG has the protective effect on acute myocardial I-R injury in rats, probably by reducing myocardium ischemia area and incidence rate of arrhythmias and ameliorating morphology and uhrastructure of myocardium.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2009年第1期115-118,196,共5页
Journal of Jilin University：Medicine Edition
基金
中央保健局科研基金资助课题(2006)
