胃癌中BORIS的表达及其临床意义

Expression and clinical significance of BORIS in gastric carcinoma

目的检测胃癌组织中BORIS的表达,探讨其临床意义。方法采用RT-PCR及Western-blot技术检测39例胃癌及18例正常胃组织中BORIS的表达。结合胃癌的临床生物学特性分析BORIS表达与胃癌组织学类型、淋巴结转移等因素的关系。结果BORIS在正常胃组织中无表达,而在胃癌组织中均有表达,其表达量的多少与患者的性别、年龄无关,而与组织学分级及有无淋巴结转移有关。结论BORIS在胃癌中表达异常可能与胃癌的发生有关,可能作为一种新的肿瘤标记物在胃癌的诊断中起一定作用。

Objective To detect the expression of BORIS in gastric carcinoma and investigate its clinical significance. Methods RT - PCR and Western blot were used to detect the expression of BORIS in 39 gastric carcinoma and 18 normal gastric tissues. The significance of BORIS expression was analysed according to the pathological characters of gastric carcinoma. Results There was no expression of BORIS in normal gastric tissues, but abundant expression in gastric carcinoma. The expression of BORIS had no close relationship with sex, age, and was correlated with grade of histology and metastasis of lymphaden. Conclusion The abnormal expression of BORIS in gastric carcinoma is correlated with its carcinogenesis, which may be a new tumor marker in the diagnosis of gastric carcinoma.