门诊抗风湿药的使用及处方分析

Review of antirheumatic drugs in outpatient prescription in Luoyang Orthopedic Hospital

目的了解本院门诊抗风湿药物的使用情况，为临床合理、有效应用抗风湿药提供参考。方法采用WHO推荐的限定日剂量（DDD）、药物利用指数（DUI）等方法，对本院2007年11月处方6872张中的抗风湿药物处方1236张进行分析。结果抗风湿药物以二联和三联及以上用药为主，其中二联378张（30．58％），三联及以上752张（60．84％）。使用频率最高的药物种类是非甾体抗炎药（52．41％）。使用频率居前三位的药物是奈丁美酮、氨基葡萄糖、柳氮磺吡啶，大部分药物的DUI值≤1，只有双氯芬酸钾、白芍总苷略大于1。结论本院抗风湿药物使用情况基本趋于合理，以非甾体类抗炎药、氨基葡萄糖和改变病情抗风湿药为主，部分不合理用药情况应引起临床医师关注。

Objective To analyze the usage of antirheumatie drugs in outpatient prescription in our hospital and provide references for rational use of antirbeumatic drugs in the clinic. Methods The age and disease of the patients were analyzed, and the frequency of usage and the rationality of antirheumatic drugs in November 2007 were analyzed according to the DDDs order and DUI. Results Of the total prescription reviewed, combination of two, three and more drugs were up to 91.42%. The use of nabumetone, Glueosamine sulfate and sulfasalazine were most frequently used. The DUIs of most drugs were less than 1 except Diclofenac kalium and total glucosides of paeony. Conclusion Overall, the usage of the antirheumatic drugs is reasonable at Luoyang Orthopedic hospital.