摘要
目的探讨胃肠道间质瘤（GIST）的诊断和治疗。方法对我院2001年12月至2006年5月收治的45例临床资料完整GIST患者的临床表现、治疗方法及病理结果进行回顾性分析。结果45例均行手术治疗，其中良性5例（11．1％），潜在恶性13例（28．9％），恶性27例（60．0％），免疫组织化学Ⅲ型跨膜蛋白酪氨酸激酶生长因子受体蛋白（CD）117、CD34阳性表达均为24例（93．3％）。23例获随访，随访时间5～64个月，其中3例死亡，1例出现肝转移。结论GIST缺乏特异性临床表现，术前确诊率低，多以黑便、腹痛和腹部肿块为主要症状；治疗上以手术治疗为主，术后辅以酪氨酸激酶抑制剂治疗具有较好疗效。
Objective To explore the diagnosis and treatment of gastrointeretinal stromal tumor （GIST）. Methods Forty-five patients with GIST were enrolled from December 2001 to May 2006. Results Forty-five cases were given surgical treatment. 5 cases were proved to be benign tumor（ 11.1% ）, 13 eases were latent malignant tumor （28.9 % ） and 27 cases （60%） were malignant tumor in the post-operation pathology. Immunohistochemistry revealed that the positive rate of CDll7 and CD34 were 93.3% and 93.3% respectively. 23 cases were followed up from 5 to 64 months. 3 cases died and one had liver metastasis. Conclusion GIST is lack of specific clinic symptoms and pro-operation diagnostic rate is relatively low. However, dark stools, stomachache and abdominal mass are main symptoms and signs. The patients have better therapy effects with surgery and tyrosine kinase inhibitors.
出处
《中国医药》
2009年第2期150-152,共3页
China Medicine
关键词
胃肠道间质瘤
手术治疗
酪氨酸激酶抑制剂
Gastrointestinal stromal tumor
Surgical treatment
Tyrosine kinase inhibitors
