1Felson T, Anderson JJ, Boersm M, et al. The American College of rheumatology priminary core set of diseases activity measures for rheumatoid arthritis. The Committee on Outcome Measures in Rheumatoid Arthrtis Clinical Trials[J]. Arthritis Rheum, 1993,36(6) :729-740.
2韩星海.现代风湿病治疗学[M].北京:人民军医出版,2000:178-179.
3Larsen A, Kvien TK, Schattenkirehner M, et al. Slowing of disease progression in rheumatoid arthritis during long-term treatment with leflunomide sulfasalazin[J]. Stand J Rheumatol, 2001,30(3) : 135-142.
4Fox RI. Mechanism of action of leflunmide[J]. J Rheumatol Suppl,1998,53:20-26.
5Cutolo M, Capellino S, Montagna P, et al. Anti-inflammatory effects of leflunomide in combination, with methotrexate on coculture of T lymphocytes and synovia lmaerophages from rheumatoid arthritis patients[J]. Ann Rheum Dis, 2006,65 (6): 728-735.
1ARNETT F C, EDWORTHY S M, BLOCK D A,et al. The American rheumatism association 1987 revised criteria for the classifycation of rheumatoid arthritis[J]. Arthritis Rheum,1988,31(3):315-324.
2SMOLEN J S, KALDEN J R,SCOTT D I,et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomized,multicentre trial[J]. Lancet, 1999,23(1):259-266.
3FOX R I. Mechanism of action of leflunomide in rheumatoid arthritis[J]. J Rheumatoid, 1998,25 (suppl): 20-26.
4RUCKERMANN K,FAIRBANKS L D, CARREY L A, et al. Leflunomide inhibits phrimidine denovo synthesis in mitogen-stimulated T lymphocytes from healthy humans[J]. J Biol Chem, 1998,273(34):21682-21691.
5O'DELL J R,LEFF R,BAULSEN G,et al.Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine,methotrexate and sulfasalazine or a combination of the three medications.results of a two-year,randomized,double-blind,placebo-controlled trial[J].Arthritis Rheum,2002,46(5):1164-1170.
6LANDEWE R B M,BOERS M,VERHOEVEN A C,et al.COBRA combination therapy in patients with early rheumatoid arthritis :long-term structural benefits of a brief intervention[J].Arthritis Rheum,2002,46(2):347-356.
7ARNETT F C,EDWORTHY S M,BLOCH D A,et al.The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis[J].Arthritis Rheum,1988,31(3):315-324.
8BRUCE B,FRIES J F.The Stanford Health Assessment Questionnaire: dimensions and practical applications[J].Health Qual Life Outcomes,2003,1(1):20.
9KREMER J,GENOVESE M,CANNON G W,et al.Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy:open-label extension of a randomized,double-blind,placebo controlled trial[J].J Rheumatol,2004,31(8):1521-1531.
10American College of Rheumatology Subcommittee on rheumatoid arthritis guidelines.Guidelines for the management of rheumatoid arthritis 2002 update[J].Arthritis Rheum,2002,46(2):328-346.
9Larsen A,Kvien TK,Schattenkirchner M,et al.Slowing of Disease Progression in Rheumatoid Arthritis during Long-Term Treatment with Leflunomide Sulfasalazin[J].Scand J Rheumatol,2001,30(3):135-142.
