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核苷类逆转录酶抑制剂线粒体毒性发病机制的研究进展 被引量：3

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作者 孙玉 陈德喜
机构地区 首都医科大学附属北京佑安医院性病艾滋病实验室
出处 《临床荟萃》 CAS 2009年第4期352-354,共3页 Clinical Focus
基金 国家自然科学基金面上项目(30770742)
关键词 获得性免疫缺陷综合征 线粒体 HIV-1逆转录酶
分类号 R593.32 [医药卫生—内科学]
  • 相关文献

参考文献23

  • 1Taylor RW,Chinnery PF, Turnbull DM, et al. In-vitro genetic modification of mitochondrial function[J]. Hum Reprod, 2000, 15(Suppl 2) :79-85.
  • 2Wallace DC. Mouse models for mitoehondrial disease[J]. Am J Med Genet,2001,106(1) :71-93.
  • 3Arnaudo E,Dalakas M, Shanske S, et al. Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy[J]. Lancet, 1991,337 (8740) : 508-510.
  • 4Lewis W, Gonzalez B, Chomyn A, et al. Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria[J]. J Clin Invest, 1992,89 (4) : 1354-1360.
  • 5Yamanaka H, Gatanaga H, Kosalaraksa P, et al. Novel mutation of human DNA polymerase gamma associated with mitochondrial toxicity induced by anti-HIV treatment [J]. J Infect Dis,2007,195(10) :1419-1425.
  • 6Shikuma CM,Day LJ ,Gerschenson M. Insulin resistance in the HIV-infected population: the potential role of mitochondrial dysfunction[J]. Curr Drug Targets Infect Disord, 2005,5 (3) : 255-262.
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  • 8Lewis W, Day BJ, Copeland WC. Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective[J]. Nat Rev Drug Diseov, 2003,2(10) : 812-822.
  • 9Lewis W,Simpson JF,Meyer RR. Cardiac mitochondrial DNA polymerase- gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine[J]. Circ Res, 1994,74(2) : 344-348.
  • 10Martin JL, Brown CE, Matthews-Davis N, et al. Effects of antiviral nucleoside analogs on human DNA polymerases and mitoehondrial DNA synthesis [ J ]. Antimierob Agents Chemother, 1994,38(12) : 2743-2749.

同被引文献69

  • 1江雪艳（译）,卢洪洲（审校）.HAART进展[J].世界感染杂志,2007,7(2):176-177. 被引量：8
  • 2章银娣,段兴钧.艾滋病免费抗病毒药物的不良反应[J].大理学院学报（综合版）,2007,6(B06):234-235. 被引量：5
  • 3Bessen LJ, Greene JB, Louie E, et al. Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC[J]. N Engl J Med, 1988, 318(11): 708.
  • 4Simpson DM, Slasor P, Dafni U, et al. Analysis of myopathy in a placebo-controlled zidovudine trial [ J ]. Muscle Nerve, 1997, 20(3) :382-385.
  • 5Peters BS, Winer J, Landon DN, et al. Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS[J]. QJMed, 1993, 86(1):5-15.
  • 6Helbert M, Fletcher T, Peddle B, et al. Zidovudine-associated myopathy[J]. Lancet, 1988, 2(8612) :689-690.
  • 7Arnaudo E, Dalakas M, Shanske S, et al. Depletion of muscle mltochondrial DNA in AIDS patients with zidovudine-induced myopathy[ J ]. Lancet, 1991, 337 (8740) : 508 -510.
  • 8Klopstock T. Drug-induced myopathies [ J ]. Curr Opin Neurol, 2008, 21(5):590-595.
  • 9Masini A, Scotti C, Calligaro A, et al. Zidovudine-induced experimental myopathy: dual mechanism of mitochondrial damage[ J]. J Neurol Sci, 1999, 166 (2) :131- 140.
  • 10Scruggs ER, Dirks Naylor AJ. Mechanisms of zidovudineinduced mitochondrial toxicity and myopathy [ J ]. Pharmacology, 2008, 82 ( 2 ) : 83-88.

引证文献3

二级引证文献6

临床荟萃
2009年 第4期

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