趋化因子CCL21与冠心病相关性研究

Relationship between chemokine CCL21 and coronary heart disease

目的探讨趋化因子CCL21与冠心病的关系。方法根据临床诊断标准及冠状动脉造影结果,将68例冠心病患者分为稳定型心绞痛组(22例)和急性冠状动脉综合征组(46例),另取20例冠状动脉造影正常者为对照组;采用酶联免疫吸附测定法检测血清CCL21的水平,应用Gensini积分系统衡量冠状动脉病变程度。结果急性冠状动脉综合征组血清CCL2水平明显高于稳定型心绞痛组,而稳定型心绞痛组血清CCL21水平又明显高于对照组,(180.1±42.6)ng/L vs(145.3±33.7)ng/L vs(105.8±33.9)ng/L(均P<0.01);血清CCL21水平和冠状动脉Gensini积分呈显著正相关(r=0.466,P<0.01)。结论血清CCL21水平可能反映了冠状动脉粥样硬化病变程度,并在斑块不稳定过程中起了重要作用。

Objective To investigate the relationship between chemokine CCL21 and coronary heart disease. Methods Sixty-eight patients with coronary heart disease were divided into two groups：stable angina group and acute coronary syndrome group. Twenty persons with normal results of coronary artery graphy were included as control group. Serum CCL21 levels were measured by enzyme-linked immunosorbent assay,the severity of coronary artery was measured by Gensini scoring system. Results Serum CCL21 level in acute coronary syndrome group was significantly higher than that in stable angina group and the latter＇s was significantly higher than that in the control group （180.1±42.6） ng/L vs （145.3±33.7） ng/L vs （105.8±33.9） ng/L （all P〈0.01）. CCL21 level and Gensini score were significantly positive correlated（r=0.466, P〈0.01）. Conclusion Serum CCL21 level may reflect the severity of coronary artery disease and play an important role in plaque destabilization.