肉豆蔻酸-2-羟基-3-磺酸钠丙酯的合成

Synthesis of myristic-2-hydroxy-3-propane sulfonic acid sodium salt

以亚硫酸氢钠、环氧氯丙烷、磷酸钠和肉豆蔻酸等为原料,合成了肉豆蔻酸-2-羟基-3-磺酸钠丙酯,探索了反应温度、催化剂、反应时间、反应物物质的量比等因素对合成的影响。结果表明,适宜的反应条件为:①合成3-氯-2-羟基丙磺酸钠:环氧氯丙烷滴加到亚硫酸氢钠溶液中,反应时间3.5 h,反应温度85℃,②合成环氧丙磺酸钠:3-氯-2-羟基丙磺酸钠加入磷酸钠溶液中,反应温度55℃,反应时间4.0 h;③合成肉豆蔻酸-2-羟基-3-丙磺酸钠:环氧丙磺酸钠溶液滴加到90℃的肉豆蔻酸溶液中,反应时间3.0 h,产率为85.2%。对产品进行了红外光谱表征,产品显示了较好的表面活性。

The myristic-2-hydroxy-3-propane sulfonic acid sodium salt was synthesized from sodium bisulrite, epichlorohydrin, sodium phosphate and myristic acid. The influence factors of temperature, amount of catalyst, reaction time and reactant ratio on conversion were studied. The favorable conditions of synthesizing were determined： Epichlorohydrin was dropped into the solution of sodium bisulfite at 85 ℃ and reaction time 3. 5 h, 3-chlorine-2-hydroxy-propane sulfonic acid sodium was synthesized; 3-chlorine-2- hydroxy-propane sulfonic acid sodium was dropped into the solution of sodium phosphate at 55 ℃ and reaction time 4.0 h. The oxiranemethane sulfonic acid sodium salt was synthesized; The oxiranemethane sulfonic acid sodium salt solution was dropped into the solution of myristic acid at 90 ℃ and reaction time 3.0 h. Myristic acid-2-hydroxy-3-propane sulfonic acid sodium salt was synthesized. The yield of myristic acid-2-hydroxy-3-propane sulfonic acid sodium salt was 85.2 %. The product was characterized by FTIR. The surfactant product showed good surface activity.