新型3-C-支链呋喃核糖衍生物的立体选择性合成

Stereoselective Synthesis of Novel 3-C-branched Ribofuranose Derivatives

在KF存在下，3-氧化木糖与亲核试剂发生加成反应，立体选择性地合成了4个新型3-C-支链呋喃核糖衍生物（2—5，其中4用生物方法脱苯甲酰基保护得6），其结构经^1H NMR，IR，HR—MS表征；2的绝对构型由X-射线单晶衍射分析确证。

Four novel 3-C-branched ribofuranose derivatives （2 - 5） were stereoselectively synthesized by the addition reaction of xylose oxide and nucleophilic reagents in the presence of KF. Debenzoyl product was obtained from 4 by biological transformation. The structures were characterized by ^1H NMR, IR and HR-MS. The absolute configuration of 2 was confirmed by XRD.