背驼式肝移植治疗肝豆状核变性

Piggyback hepatic transplantation for treatment of Wilson disease

目的探讨背驼式肝移植术，解决肝豆状核变性铜代谢障碍，延长患者生存时间，改善患者的生存质量。方法２例病人采用经典式同种异体原位肝移植术，３例采用背驼式同种异体原位肝移植术，术后应用环孢霉素Ａ抗免疫治疗。结果采用经典式手术２例病人手术后分别于１７、３９天死亡，采用背驼式３例病人中２例存活至今（分别术后２．３年和０８年），且生存质量明显改善。结论背驼式肝移植是治疗肝豆状核变性的一种优选方法。

Objective Hepatic transplantation was performed on patients with Wilson disease to correct the disorder of copper metabolism, and to prolong lifetime and improve living quality. Methods Two cases of Wilson disease were treated with classic homograft orthotopic hepatic transplantation and 3 case by piggyback homograft orthotopic hepatic transplantation with administration of cyclosporin A. [WT9.HZ〗Results The former 2 cases died 17 and 39 days after operation whereas so far 2 of the later 3 cases have been alive with evidently good living quality. Conclusion Piggyback liver transplatations is a good treatment for Wilson disease.