胃癌c-erbB-2及增殖细胞核抗原表达与预后的关系

The Prognostic Significance of Expression of cerbB2 and Proliferating Cell Nuclear Antigen in Gastric Cancer.

目的：探讨胃癌ｃｅｒｂＢ２及增殖细胞核抗原（ＰＣＮＡ）表达与预后的关系。方法：应用免疫组化ＡＢＣ法对１０３例胃癌胃镜活检组织进行检测。结果：分别有１９例与５３例出现ｃｅｒｂＢ２阳性表达及高ＰＣＮＡ阳性标记（＞３５６１％），两者表达与胃癌大体类型、进展程度、组织类型、分化程度及有无伴淋巴结及肝转移情况密切相关。高ＰＣＮＡ阳性标记者ｃｅｒｂＢ２表达阳性率高，５年生存率低；高中分化胃癌中，ｃｅｒｂＢ２表达阳性者５年生存率显著低于阴性者。

Aim: To study the prognostic significance of expression of cerbB2 and proliferating cell nuclear antigen (PCNA) in gastric cancer. Method: Immunohistochemical reactivity to cerbB2 protein and PCNA was examined in bioptic specimens from endoscopy of 103 patients with gastric cancer.Results: 19 and 53 cases of 103 patients were positive for cerbB2 expression and high PCNA labeling index(>35.61%)respectively. There were significant differences in morphologic type,depth of tumor invasion,histology,differentiation,lymph node and liver metastasis between positive and negative cerbB2 expression,high and low PCNA labeling index groups.The incidence of cerbB2 positivity was significantly higher in high PCNA index group which had poorer 5-year survival rates than in low PCNA index group. Patients with cerbB2-positive tumors had poorer 5-year survival rates than those with cerbB2-negative ones in the well to moderately differentiated carcinoma. Conclusions:The results showed that the cerbB2 and PCNA expression was a helpful prognostic factor for gastric cancer.