纳洛酮对脑卒中血浆ET、CGRP、NPY变化的影响

The effects of naloxone on ET,CGRP and NPY in plasma concentration of patients with acute cerebral stroke

目的:观察纳洛酮对脑卒中患者血浆内皮素(ET)、神经肽Y(NPY)、降钙素基因相关肽(CGRP)水平的影响。方法:放射免疫法测定脑梗塞和脑出血患者血浆ET、NPY、CGRP水平变化,并与对照组进行比较。结果:脑梗塞和脑出血发病1周内血浆ET、NPY水平明显升高,纳洛酮治疗组血浆ET(第1、3、7天)和NPY(第1、3天)水平低于常规治疗组;脑梗塞和脑出血血浆CGRP在发病24h内升高之后逐渐下降,纳洛酮治疗组血浆CGRP(第1、3、7天)高于常规治疗组。结论:脑梗塞及脑出血患者早期应用纳洛酮可显著降低ET和NPY水平、升高CGRP水平,从而保护脑细胞、促进神经功能的恢复。

Objective： To study the effects of naloxone on endothelin（ET）, neuropeptide Y（NPY） and calcilonin gene -related peptide （CGRP） in plasma concetration of patients with acute cerebral stroke. Methods： The levels of ET, CGRP and NPY were detected with radio- immunoassay（RIA） in plasma of patients with cerebral infarction（CI） and cerebral hemorrhage（CH） , which were compared with that of the normal control group. Results： The plasma levels of ET and NPY within 1 week in patients with CI and CH were significantly higher than those in the normal control group. The plasma levels of ET of naloxone treatment group in patients with CI and CH （1d, 3d, 7d） were significantly lower than those in routine treatment group. The plasma levels of NPY of patients with CI and CH（ 1d, 3d） were significantly lower than those of routine treatment group. The plasma levels of CGRP in patients with CI and CH ascended in 24 hour after stroke, and then decreased gradually in a week. The plasma levels of CGRP of naloxone treatment group（ 1d, 3d,7d） were significantly higher than those of routine treatment group. Condusions： The application of naloxone in early stage of CI and CH can decrease plasma levels of ET and NPY, and increase plasma levels of CGRP. So naloxone can protect cerebral cells, promote the recovery of neurocyte flmction.