胃肠道粘膜相关组织恶性淋巴瘤32例临床病理观察

Malignant Lymphoma Arising from gastrointestinal Mucosa associated lymphoid Tissue ——A Clinic-pathological Observation of 32 Cases

目的：提高对胃肠粘膜淋巴组织起源的恶性淋巴瘤的认识，以减少误诊、漏诊。方法：３２例胃肠道恶性淋巴瘤标本、ＨＥ染色、部分附加Ｆｏｏｔ、ＭＧＰ、ＰＡＳ、免疫标记Ｋａｐｐｙ、Ｌａｍｂｄａ轻链、ＥＭＡ、Ｋｅｒａｔｉｎ和ＣＥＡ。结果：病灶多局限于胃肠道，形态学由中心细胞样细胞组成，常伴有淋巴上皮损害及残存滤泡。

Aim:To Recognize primary gastrointestinal malignant lymphoma (PMLGI)arsing from mucosa associated lymphoi Tissue (MALT) and to reduce the rates of misdiagnosis and missed diagnosis.Methods: The pathological sections of 32 cases of PMLG were stained with hematoxylin and eosin.Some of them were added Foot,MGP,PAS stain and were studied by immunoenzyme labelling methods,such as Kappa light chain,Lambda light chain,EMA,Keratin and CEA.Results: The lesions often remained locolized in gastrointestine.The tumours consisted of centrocyte-like cells,frequently accompanying with lymphoepithelial lesions and residual germinal centers.Conclusion: The above described pathological changes and immunohistochemistry changes are helpful to the diagnosis of PMLGI.