摘要
目的探讨充血性心衰(CHF)并贫血的患者,在EPO加铁剂治疗后,对心脏结构与功能及B型利钠肽水平的影响。方法32例连续CHF并贫血(80g/L<血红蛋白<120g/L)的患者纳入本研究。以随机方法分为治疗组(A组、16例),皮下注射EPO12000IU/周+每天口服铁剂共4个月。对照组(B组、16例),每天口服铁剂。结果A组患者在随机治疗的4个月中,相对于基础状态血红蛋白增加(P<0.001),左室内径缩小(P<0.001),射血分数增加(P<0.05),心功能分级(P<0.001)与6min步行试验(P<0.05)改善,同时血浆中B型利钠肽水平(P<0.01)下降。B组患者在试验期间射血分数(P<0.05)及6min步行距离(P<0.05)有所下降,其他指标无明显变化。结论CHF并贫血患者,EPO加口服铁剂治疗,能改善患者的心脏结构与功能,降低B型利钠肽水平。
Objective To study the effects of erythropoietin ( EPO ) plus oral iron on cardiac construction, function and B-natriuretic peptide (BNP) level in patients with congestive heart failure (CHF) and anemia. Methods Thirty-two consecutive subjects with CHF and anemia were enrolled into the study. They were randomized into trial group (Group A, n = 16) and control group ( Group B, n = 16). Group A was administered hypodermal EPO for four months ( 12,000 iu/week) in addition to daily oral iron, and meanwhile Group B took daily oral iron alone. Results With respect to the baseline, the patients in Group A demonstrated an increase in hemoglobin (P 〈 0. 001 ), a reduction in left ventricular diastolic diameter (LVDD) (P 〈 0. 001 ), an increase in left ventricular ejection fraction (LVEF) (P 〈 0.05 ), an improvement in new York Heart Association functional class ( P 〈 0. 001 ) and 6 - minute walking testing ( P 〈 0.05 ) and a decrease in plasma BNP level ( P 〈 0.01 ) ; and those in Group B showed a fall in LVEF ( P 〈 0.05 ) and in distance of 6 - minute walking testing ( P 〈 0.05 ) , and showed no differences in other indexes. Conclu' sion In anemic CHF patients, correction of anemia with EPO and iron leads to improvements in cardiac construction and function, and a fall in plasma BNP level.
出处
《临床军医杂志》
CAS
2009年第1期10-12,共3页
Clinical Journal of Medical Officers
关键词
充血性心衰
贫血
心脏结构
心功能
促红细胞生长素
congestive heart failure
anemia
cardiac construction
cardiac function
erythropoictin