急性心肌梗死患者B型钠尿肽的变化

B-natriuretic Peptide Used for Assessment of Heart Function in Patients with Acute Myocardial Infarction

目的探讨急性心肌梗死患者血浆B型钠尿肽水平变化的意义。方法利用美国德灵公司(DADE BEHRING)全自动生化分析仪及其配套试剂测定60例急性心肌梗死患者及60例健康者血浆B型钠尿肽的水平,并参照心脏超声检查左心室功能结果进行分析。结果急性心肌梗死患者血浆B型钠尿肽水平显著高于健康对照组;心功能Killip3～4级组血浆B型钠尿肽水平也明显高于Killip1～2级组;左心室射血分数≤40%者显著高于左心室射血分数>40%者,差异均具有显著统计学意义。结论急性心肌梗死时血浆B型钠尿肽水平明显升高,与心功能的变化密切相关。

Objective To explore the clinical significance of the change in B-natriuretic peptide （BNP） in acute myoeardial infarction （AMI）. Methods The BNP levels of 60 patients diagnosed as AMI by coronary angiography and 60 healthy controls were detected by DADE BEHRING clinical chemistry system. Results The BNP level of the AMI patients was higher than that of the controis. The BNP level was higher in the AMI patients with a heart function of Killip 3 - 4 than in those with Killip 1 - 2, and the BNP level was also higher in the AMI patients with a LVEF≤40% than in those with a LVEF 〉40%. All the differences were significant. Conclusion BNP of AM1 patients is related with heart function.