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病毒性脑炎患儿血清及脑脊液TNF-α、IL-6、NSE的变化及其临床意义 被引量:22

Changes in TNF-α, IL-6 and NSE levels in Serum and Cerebrospinal Fluid of Children with Viral Encephalitis and Their Clinical Significance
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摘要 目的探讨病毒性脑炎儿童血清及脑脊液TNF-α、IL-6、NSE的动态变化及其临床意义。方法66例病毒性脑炎患儿进行血清及脑脊液TNF-α、IL-6、NSE的测定,另有10名临床排除中枢神经系统感染的儿童作为对照组,也进行血清及脑脊液TNF-α、IL-6、NSE测定。TNF-α、IL-6应用ELISA法检测。NSE用放射免疫法进行测定。结果病毒性脑炎组血清及脑脊液TNF-α、IL-6、NSE水平均明显增高,较对照组有显著统计学差异(P<0.01);脑脊液中TNF-α、IL-6、NSE水平与血清中TNF-α、IL-6、NSE水平呈正相关[r(TNF-α)=0.338,P<0.01;r(IL-6)=0.256,P<0.01;r(NSE)=0.374,P<0.01];病毒性脑炎组血清及脑脊液中IL-6与NSE水平之间无相关性[r(s)=0.108,P>0.05;r(csf)=0.145,P>0.05],TNF-α与NSE水平有直线相关性[r(s)=0.387,P<0.01;r(csf)=0.401,P<0.01]。结论脑脊液和血清中NSE可作为判断病毒性脑炎患儿脑组织损伤的客观指标之一,TNF-α、IL-6参与了儿童病毒性脑炎的病理过程,血清及脑脊液中TNF-α、IL-6水平检测对儿童病毒性脑炎的诊断有一定临床意义。 Objective To study the changes in tumor necrosis factor (TNF) -α, interleukin ( IL)-6 and neuron-specific-enolase (NSE) levels in serum and cerebrospinal fluid of children with viral encephalitis and their clinical significance. Methods The TNF-α, IL-6 and NSE levels in the serum and cerebrospinal fluid of 66 children with viral encephalitis were measured, and another 10 children without central nervous system infection were selected as controls. The TNF-α and IL-6 levels were measured with ELISA and the NSE levels with radioimmunolgical method. Results The TNF-α, IL-6 and NSE levels in the serum and cerebrospinal fluid of the viral encephalitis group increased significantly at acute stage, and there were significant deferences between viral encephalitis group and the control group (P 〈 0.01 ). There were positive correlations on TNF-α, IL-6 and NSE levels between in serum and in ccrebrospinal fluid in the viral encephalitis group [ r(TNF-α) = 0. 338, P 〈 0.01 ; r( IL-6 ) = 0. 256, P 〈 0.01 ; r (NSE) = 0. 374, P 〈 0. 01 ]. There was no correlation between the levels of IL-6 and NSE in serum or in cerebrospinal fluid in the viral encephalitis group [ r(serum) = 0. 108, P 〉 0. 05 ; r( cerebrospinal fluid) = 0. 145, P 〉0. 05 ]. There was positive correlation between the levels of TNF-α and NSE in serum or cerebrospinal fluid in the viral encephalitis group [ r(serum) = 0. 387, P 〈 0. 01 ; r( cerebrospinal fluid) = 0. 401, P 〈 0. 01 ]. Conclusion NSE level in cerebrospinal fluid or serum may be used as an objective standard retlectiong the degree of brain injury. TNF-α and IL-6 play roles in the pathogenesis of encephalitis in children. The measurement of TNF-α and IL-6 levels is valuable for judging the seriousness of virus encephalitis in children.
出处 《临床军医杂志》 CAS 2009年第1期69-71,共3页 Clinical Journal of Medical Officers
关键词 病毒性脑炎 儿童 神经元特异性烯醇化酶 肿瘤坏死因子-α 白介素-6 viral encephalitis children neuron-specific-enolase tumor necrosis factor-or interleukin-6
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