丝裂霉素滴眼液在带蒂结膜瓣移植术后应用的临床观察

Clinical Study on Use of Mitomycin C Eye Drop after Autologous Conjunctiva-flap Transplantation

目的观察带蒂结膜瓣移植及术后应用丝裂霉素滴眼液治疗翼状胬肉的临床疗效。方法选择初发性翼状胬肉患者98例(130眼),随机分成3组:A组29例(38眼),行翼状胬肉切除术,术后常规使用皮质类固醇滴眼液点眼治疗,B组35例(47眼),C组34例(45眼),采用翼状胬肉切除联合带蒂结膜瓣移植术,术后B组常规使用皮质类固醇滴眼液点眼,C组应用0.1g/L丝裂霉素联合皮质类固醇滴眼液点眼治疗。结果随访观察6～24个月,A组有11眼复发,复发率28.95%,B组有4眼复发,复发率8.51%,C组有1眼复发,复发率2.22%。结论翼状胬肉切除联合带蒂结膜瓣移植的手术方式及术后应用丝裂霉素滴眼液可有效降低复发率。

Objective To observe the clinical effect of mitomycin C eye drop after autologous conjunctiva-flap transplantation for pterygium. Methods A total of 130 eyes with primary pterygium of 98 patients were divided into three groups. Group A（38 eyes of 29 patients） was treated by pterygium excision, and then treated with eortieosteroid eye drop. Group B （47 eyes of 35 patients） and Group C （45 eyes of 34 patients） were treated by autologus conjunctiva-flap transplantation. Then Group B was treated with cortieosteroid eye drop, and Group C was treated with 0.1 mg/ml mitomycin C eye drop plus eorticosteroid eye drop. Results According to the follow-up from 6 to 24 months, the recurrence rate was 28.95% in Group A, 8.51% in Group B, and 2.22% in Group C. Conelusion In addition to autologous conjunct ira-flap transplantation, the use of mitomyein C eye drop after operation can prevent the recurrence of pterygium.