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不同发作类型癫痫患儿血清抗心磷脂抗体变化及临床意义

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摘要 目的探讨不同发作类型癫疴患儿血清抗心磷脂抗体水平的变化及其临床意义。方法采用ELISA法检测84例癫疴患儿治疗前后及38例正常儿童血清抗心磷脂抗体水平。结果健康对照组、部分发作组、全身发作组及分类不明发作组血清抗心磷脂抗体阳性率分别为6.3%(2/32)、28.6%(8/28)、33.3%(12/36)、30.0%(6/20),各组比较差异有显著性(χ^2=9.98,P〈0.05);部分发作组、全身发作组及分类不明发作组血清抗心磷脂抗体阳性率均明显高于健康对照组(P〈0.01),癫痫不同发作类型组间比较差异无显著性(P〉0.05)。部分发作组、全身发作组及分类不明发作组癫痫患儿在治疗后血清抗心磷脂抗体阳性率明显降低,差异有显著性(χ^2=5.39,P〈0.05;χ^2=14.40,P〈o.01;χ^2=11.67,P〈0.01)。结论癫痫患儿血清抗心磷脂抗体水平增加,提示癫痼发作中可能存在自身免疫异常;治疗后血清抗心磷脂抗体水平降低,为癫痫的有效防治提供重要依据。
出处 《中国小儿急救医学》 CAS 2009年第1期58-59,共2页 Chinese Pediatric Emergency Medicine
基金 甘肃省自然科学基金项目(3ZS051-A25-087)
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