乳腺癌超声和钼靶X线表现与ER、PR、C-erbB-2表达的相关性研究

Correlation between the Ultrasonography and Mammographic Features with the Expression of ER,PR,C-erbB-2 in Breast Cancer

目的探讨乳腺癌超声和钼靶X线表现与ER、PR、C-erbB-2因子表达之间的相关性。方法采用PV-6000免疫组化法检测87例乳腺癌中ER、PR、C-erbB-2的表达情况,分析其与超声和钼靶X线表现的相关性。结果87例乳腺癌患者中,超声表现肿块形态规则和边界清晰组ER、PR阳性表达率高,病变区有钙化和血流者C-erbB-2阳性表达率高;钼靶X线表现肿块边缘毛刺征者ER、PR阳性表达率高,病变区有钙化和结构扭曲者C-erbB-2阳性表达率高,病变区高密度和结构扭曲ER、PR阳性表达率低。结论乳腺癌超声表现和钼靶X征象与ER、PR、C-erbB-2的表达有密切关系,在一定程度上反映了ER、PR、C-erbB-2的表达状态,为乳腺癌的术前辅助内分泌治疗和预后评估提供了一定的信息。

Objetive To investigate the correlation between the ultrasonography and mammogaphic features with the expression of ER, PR, C-erbB-2 in breast cancer. Methods Eighty-seven cases of breast carcinoma were studied by means of PV-6000 immunohistochemistry and study the correlation of the expression of ER, PR, C-erbB-2 with the ultrasonography and mammogaphic features. Results Among the 87 cases, about the ultrasonography features, ER and PR positive rates were higher in regular shape and clear boundary groups.C-erbB-2 positive rate was higher in calcification and bloodstream.;About the mammogaphic features, ER and PR positive rates were higher in spiculated tumor and C-erbB-2 positive rate was higher in calcification and structural disorder lesions. However, ER and PR positive rates were lower in hyperdensity and structural disorder lesions. Conclusion Some important ultrasonography and mammographic features of breast cancer were closely related to the expression of ER,PR and C-erbB-2, which can reflect the expressed state of ER, PR and C-erbB-2 and provide more information about the preoperative adjuvant endocrine therapy and the evaluation of prognosis.