术中植入^(125)I粒子内放疗治疗脑胶质瘤长期疗效观察

Clinical study of long term therapeutic efficacy of brain gliomas treated by interstitial brachytherapy of ^(125)I seeds implanted in operation

目的探讨术中植入125I粒子内放疗治疗胶质瘤术后长期疗效。方法将该院近几年胶质瘤患者分为:治疗组(手术切除加瘤巢内放疗组)和对照组(单纯手术切除组),观察2组肿瘤复发时间、生存时间、2年生存率和3年生存率。结果2组复发时间及生存时间比较,治疗组肿瘤复发时间明显延长。治疗组较对照组2年生存率和3年生存率均明显提高。结论术中植入125I粒子内放疗治疗胶质瘤,长期疗效良好,是一种安全有效的治疗脑胶质瘤的方法。

[ Objective] The aim of this protocol was to investigate long term therapeutic efficacy of malignant brain gliomas treated by interstitial brachytherapy of ^125I seeds implanted in operation prospectively. [Methods] Patients were derided into tested group and control group. We tested the death rate, the time of life and the time of recurrence. [Results] In tested group compared with control group, we found the death rate decreased and the time of life evidently extended. [ Conclusions] Interstitial braehytherapy of ^125I seeds implanted in operation can improve the quality of life. It＇s an effective method for the treatment of the malignant brain gliomas.