胃康舒对实验性慢性胃炎脾胃湿热证大鼠胃黏膜前列腺素E_2含量的影响

The Effect of Wei-kang-shu on Content of PGE_2 of Rat's Gastric Mucosa in Experimental Chronic Gastritis with Splenogastric Hygropyrexia Syndrome

目的：观察胃康舒对实验性慢性胃炎脾胃湿热证大鼠胃黏膜前列腺素E2（PGE2）含量的影响。方法：实验分设正常对照组、模型组、胃复春组、胃康舒低剂量组、胃康舒高剂量组。除正常对照组外，其余各组均采用脱氧胆酸钠结合湿热环境、饮食不节等综合因素诱发“病证结合”大鼠慢性胃炎脾胃湿热证模型。灌胃法给药，实验结束后采用放射免疫法分别检测各组胃黏膜PGE2的含量。结果：模型组大鼠胃黏膜PGE2含量低于正常组（P〈0．01），各给药组均高于模型组（P〈0．05～0．01），尤以胃康舒高剂量组更显著，但各给药组间差异无显著性（P〉0．05）。结论：胃康舒可促进胃黏膜PGE，合成，对胃黏膜细胞具有保护作用。

Objective ： To observe the effect of Wei-kang-shu on content of prostaglandin E2 （ PGE2 ） of rat＇ s gastric mucosa in experimental chronic gastritis with splenogastric hygropyrexia syndrome. Method： Five test groups were set up, which were normal control group, model group, Wei-fu-chun group, low-dose group of Weikang-shu, and high-dose group of Wei-kang-shu. Except normal control group, the other four groups were made into models of chronic gastritis with splenogastric hygropyrexia syndrome by sodium deoxycholate combining with humid heat circumstance and eating and drinking without temperance. Administration by garage was adopted. Content of PGE2 in gastric mucosa was detected by radioimmunoassay. Result： Content of PGE2 in gastric mucosa in model group was lower than that in normal control group （P 〈 0. 01 ）, but that in other medication administration groups was higher than that in model group （ P 〈 0. 05 - 0. 01 ）. Content of PGE2 was higher especially in high-dose group of Wei-kang-shu, but there was no difference among each medication administration groups （P 〉 0.05 ）. Conclusion ： Wei-kang-shu can encourage synthesis of PGE2 in gastric mucosa, and protect the cell of gastric mucosa.