新诊断2型糖尿病并高尿酸血症的相关因素分析

Analysis of the factors related to serum uric acid in newly diagnosed type 2 diabetic patients

目的探讨新诊断2型糖尿病患者合并高尿酸血症的相关因素。方法选择236例新诊断2型糖尿病患者，其中新诊断2型糖尿病并高尿酸血症116例（高尿酸组），新诊断2型糖尿病正常血尿酸120例（对照组），采用空腹C肽代替胰岛素改良HOMA公式评价胰岛素抵抗。结果高尿酸组体重指数（BMI）、腰臀比（WHR）、收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、甘油三酯（TG）和HOMA—IR（CP）高于对照组（P〈0．01；Logistic回归分析表明WHR、DBP、TG和胰岛素抵抗是新诊断2型糖尿病合并高尿酸血症形成的独立危险因素。结论新诊断2型糖尿病合并高尿酸血症与肥胖、脂代谢紊乱、血压升高、胰岛素抵抗密切相关。

Objective To investigate the clinic characteristic of hyperuricemia in newly diagnosed type 2 diabetic patients. Methods 236 newly diagnosed type 2 diabetic patients were divided into two groups ：hyperuricemia（ n = 116）and normal serum uric acid （n = 120 ）. Fasting C-peptide to replace insulin in homeostasis model assessment （HOMA） were applied to assess the status of insulin resistance. Results Patients with hyperuricemia in newly diagnosed type 2 diabetes had markedly higher body mass index （ BMI）, waist circumference （ WC ）, waist-to hip ratio, blood pressure （ BP ）, Total cholesterol （ TC ）, triglyceride （TG） and HOMA-IR（CP） than those in controls （ P 〈 0.01 for all）. Logistic regression analysis results showed that WHR, diastolic pressure（DBP） ,TG and insulin resistance were the independent risk factors of hyperuricemia in newly diagnosed type 2 diabetic patients. Conclusion Hyperuricermia of newly diagnosed type 2 diabeties was closely correlated with obesity, hyperlipemia, hypertension and insulin resistance.