非核苷类逆转录酶抑制剂的研究XVⅢ：4-烯丙基和4-叠氮基取代的三嗪类化合物的合成及抗HIV活性(英文)

Non-nucleoside reverse transcriptase inhibitors (Part 18):Synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines

在已有工作基础上,基于分子对接设计合成了8个新的4-烯丙基取代和4-叠氮基取代的二芳基三嗪类衍生物。抗HIV-1活性的测试结果表明所有新化合物均具有抗HIV-1活性。其中化合物7c不仅抑制HIV-1野生株的复制(IC50=0.034μmol·L-1,SI=6475),且对Y181C和K103C双突变酶显示出较强的抑制活性,其IC50值为9.39μmol·L-1,高于奈韦拉平。

Eight new diaryltriazine derivatives containing 4-allylamino and 4-azido substitutes guided by molecular docking have been designed and synthesized based on our previous work. The evaluation of HIV inhibitory activity demonstrated that all compounds were potent against HIV-1 replication. The most active compound 7c exhibited activity against HIV-1 （IC50 = 0.034 μmol·L^-1, SI = 6 475） and the double mutant strain （IC50 = 9.39 μmol·L^-1） in the micromolar range, which was more ootent than neviranine.