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Spectrophotometric determination of tranexamic acid using vanillin 被引量:1

Spectrophotometric determination of tranexamic acid using vanillin
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摘要 A new spectrophotometric method has been examined for the determination of the tranexamic acid (TA) by derivatization with vanillin (VAN). The molar absorptivity of TA was calculated 25 160 L·mol-1·cm-1 at λmax 354 nm and obeyed the Beer's law within 0.5-2.5 μg·mL-1. The color reaction was highly stable and did not show any change in absorbance up to 24 h. The method was applied for the analysis of TA from capsules, injections and tooth pastes. The amounts of TA found in capsules, injections and tooth pastes of various pharmaceutical companies were observed with 249.0-250.9 mg/capsule, 249.3-250.7 mg/injection and 0.048%-0.049% in tooth pastes with relative standard deviation (RSD) 0.2%-5.0% (n = 3). A new spectrophotometric method has been examined for the determination of the tranexamic acid (TA) by derivatization with vanillin (VAN). The molar absorptivity of TA was calculated 25 160 L·mol-1·cm^-1 at λmax 354 nm and obeyed the Beer's law within 0.5-2.5 μg·mL^-1. The color reaction was highly stable and did not show any change in absorbance up to 24 h. The method was applied for the analysis of TA from capsules, injections and tooth pastes. The amounts of TA found in capsules, injections and tooth pastes of various pharmaceutical companies were observed with 249.0-250.9 mg/capsule, 249.3-250.7 mg/injection and 0.048%-0.049% in tooth pastes with relative standard deviation (RSD) 0.2%-5.0% (n = 3).
出处 《药学学报》 CAS CSCD 北大核心 2009年第2期175-180,共6页 Acta Pharmaceutica Sinica
关键词 分光方法 氨甲环酸 显色反应 药物化学 tranexamic acid vanillin spectrophotometry
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  • 1Borea G, Montebugnoli L, Capuzzi P, et al. Tranexamic acid as a mouthwash in anticoagulant-treated patients undergoing oral surgery. An alternative method to discontinuing anticoagulant therapy [J]. Oral Surg Oral Med Oral Pathol, 1993, 75: 29-31.
  • 2Tibbelin A, Aust R, Bende M, et al. Effect of local tranexamic acid gel in the treatment of epistaxis [J]. J Otorhinolaryngol Relat Spec, 1995, 57: 207-209.
  • 3Fiechtner BK, Nuttall GA, Johnson ME, et al. Plasma tranexamic acid concentrations during cardiopulmonary bypass [J]. AnaesthAnalg, 2001, 92: 1131-1136.
  • 4Jansen A, Andreica S, Claeys M, et al. Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty [J]. Br J Anaesth, 1999, 83: 596- 601.
  • 5Martindale XXXI [M]. London: Royal Pharmaceutical Society of Great Britain, 1996:771-772.
  • 6Maeda K, Naganuma M. Topical trans-4-aminomethylcyclohexane carboxylic acid prevents ultraviolet radiation-induced pigmentation [J]. J Photochem Photobiol B, 1998, 47: 136-141.
  • 7Dalmau A, Sabate A, Koo M, et al. Prophylactic use of tranexamic acid and incidence of arterial thrombosis in liver transplantation [J]. Anesth Analg, 2001, 93: 516.
  • 8Ansari TM, Raza A, Atta-Ur-Rehman. Spectrophotometric determination of tranexamic acid in pharmaceutical bulk and dosage forms [J]. Anal Sci, 2005, 21: 1133-1135.
  • 9E1-Aroud KA, Abushoffa AM, Abdellatef HE. Spectropho- tometric and spectrofluorimetric methods for the determination of tranexamic acid in pharmaceutical formulation [J]. Chem Pharm Bull, 2007, 55: 364-367.
  • 10Atmaca S. Spectrophotometric determination of tranexamic acid with 2, 4, 6-trinitrobenzosulfonic acid [J]. Acta Pharm Turcica, 1989, 31: 115-118.

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