噬菌体展示抗体库技术的研究进展

Progress in Study on Phage Display Antibody Library Technique

噬菌体展示抗体库技术是一种将抗体组合文库与噬菌体表面展示技术相结合所形成的新技术,可以将抗体分子展示在噬菌体表面,且保持了抗体的天然构象和生物学活性,为人源抗体的制备提供了良好的技术平台。本文对噬菌体展示抗体库技术的原理、特点、类型及其研究进展作一综述。

Phage display antibody library technique is a novel technique developed based on combinatorial antibody library and phage surface display techniques, which displays antibody molecules on the surface of phage, maintains the natural confirmation and biological activity of antibody and provides a good technical platform for preparation of humanized antibody. The principle, character, type as well as progress in study of phage display antibody library technique were discussed in this paper.