急性胃肠道感染后功能性胃肠病

Functional Gastrointestinal Disorders after Acute Gastrointestinal Infection

功能性胃肠病（FGIDs）是一组胃肠道功能紊乱性疾病,目前研究最多的为肠易激综合征（IBS）和功能性消化不良（FD）。目前认为FGIDs主要是胃肠动力异常和内脏高敏感的结果,而在造成这些病理生理改变的原因中,胃肠道感染的作用日益受到重视。研究表明,急性胃肠道细菌感染可能是部分FGIDs的促发因素,通过持续胃肠道黏膜炎症和免疫反应引起一系列病理生理改变和相关症状,5-羟色胺和肥大细胞代谢系统异常可能是其重要的发生机制。

Functional gastrointestinal disorders （FGIDs） are a group of diseases with abnormalities of gastrointestinal functions. Up to now, irritable bowel syndrome （IBS） and functional dyspepsia （FD） are the most frequently studied entities in FGIDs. Disturbances of gastrointestinal motility and visceral hypersensitivity are now considered to be the major pathophysiologieal mechanisms of FGIDs. Gastrointestinal infection has been more and more emphasized as the factors affecting the above-mentioned pathophysiological changes. It was shown that acute bacterial gastroenteritis might be the promoting factor for a portion of FGIDs. The pathophysiologieal changes and symptoms are generated through persistent mucosal inflammation and inmmne reaction after gastroenteritis. 5-hydroxytryptamine and mast cell metabolic abnormalities might be the important pathogenesis of FGIDs.