除草剂磺草酮对大鼠血清酪氨酸水平的影响

Effect of herbicide sulcotrione on serum tyrosine level in rats

目的探讨磺草酮对大鼠血清酪氨酸水平的影响。方法大鼠每日分别ig给予磺草酮5,50和500μg·kg-1,连续28d染毒。采用高效液相法检测不同时间点大鼠血清中酪氨酸、磺草酮水平;血糖检测仪测定血糖水平。结果磺草酮50和500μg·kg-1组大鼠血清中酪氨酸和磺草酮水平较对照组显著升高,存在剂量-效应关系和时间-效应关系。各剂量组的血糖均在正常值范围。血清酪氨酸、磺草酮和血糖水平无性别间差异。结论血清酪氨酸水平可作为磺草酮引起机体反应的生物标志。低剂量磺草酮对糖代谢无显著影响。

AIM To explore the effect of herbicide sulcotrione on serum tyrosine level in rats. METHODS Rats were given ig sulcotrione 5,50 and 500μg·kg^-1 , once a day for 28 d. Tyrosine and sulcotrione concentrations in serum were detected by high performance liquid chromatagraphy and blood glucose concentra- tions by glucosemeter. RESULTS Compared with control group, tyrosine and sulcotrione concentrations in 50 and 500 μg·kg^-1 groups increased dosage- and time-dependently. Blood glucose concentrations of all groups were normal through the experiment. There were no signifi- cant difference in blood tyrosine, sulcotrione and glucose levels between male and female rats. CONCLUSION Blood tyrosine level can be used as a biomarker of biological effect caused by sulcotrione. Sulcotrione in low dosage has no significant effect on glucose metabolism.