脊髓损伤治疗药物的研究进展

Advances in research on pharmacological strategies for spinal cord injury

药物治疗是脊髓损伤(spinalcord injury,SCI)后重要处理措施之一,但由于SCI生理病理学机制复杂,使药物疗法的效用千差万别,且禁忌症、并发症各有特点,如何选择合理药物疗法以便有效保护脊髓、减少继发性损伤、促进受损神经元再生一直是脊髓损伤药物治疗研究的重点。目前,个别药物已应用于临床,大多尚处临床试验甚至临床前动物实验阶段。此文就近年来脊髓损伤药物治疗研究进展作一综述。

Aim Pharmacological intervention is one of important strategies to deal with spinal cord injury. The effect of Phar- macological intervention has highly differentiated features because of complex physiopathology mechanisms in SCI. Moreover contraindications, complications having different features, it is constantly the focal point in the selection of pharmacological intervention to protect spinal cord, attenuate secondary injury and promote injuried neuron regeneration. At present only several of those have been applied in clinic and the majority are still being carried out in clinic trial stage, even preclinical animal experiment stage. This paper made a particular review of the current situation in pharmacological intervention for spinal cord injury.