Survivin、Ki67在牙源性囊肿上皮组织中的表达及意义

The expression and significance of Survivin and Ki67 in odontogenic jaw cyst epithelium

目的:探讨根端囊肿、含牙囊肿及角化囊肿衬里上皮中Survivin、Ki67的表达及意义。方法:采用免疫组化法检测12例根端囊肿、20例含牙囊肿、22例角化囊肿中Survivin、Ki67表达水平,并加以分析。结果:Survivin在根端囊肿中无表达,在含牙囊肿和角化囊肿中表达的阳性率分别为10%、63.6%,角化囊肿OD值显著高于根端囊肿和含牙囊肿(P<0.05);Ki67在3种组织中均有表达,角化囊肿中Ki67-LI显著高于根端囊肿和含牙囊肿(P<0.05);角化囊肿中Survivin阳性表达的Ki67-LI显著高于表达阴性者(P<0.05),且Survivin表达与Ki67表达呈正相关(r=0.452,P<0.05)。结论:Survivin、Ki67在牙源性囊肿中的表达差异显示了它们具有不同的增殖和分化过程。

Objective： To investigate the expression and significance of regulators Survivin and Ki67 in the lining of odontogenic cysts .Method： Immunohistochemical technique was used to detect the expression of regulators Survivin and Ki67 in 12cases of radicular cyst （RC）, 18cases dentigerous cyst （DC） and 22cases of odontogenic keratocyst （OKC）.Result： Survivin expression was absent in RC, the positive expression rates of Survivin in DC and OKC were 10%,63.6% respectively, OD of Survivin in OKC was significantly higher than that in RC and DC （P〈0.05）. Ki67 positive stainings were observed in the three tissues, Ki67-LI in OKC was significantly higher than that in RC and DC （P〈0.05）. Ki67-LI in OKC with positive expression of Survivin was significantly higher than that with negative expression （P〈0.05）, and the expression of Survivin was positively correlated with Ki67 expression （r=0.452, P〈0.05）.Conclusion： The results demonstrate that there are differences in Survivin,Ki67 expression between epithelial linings of the major odontogenie cysts types, indicating differences in proliferation and differentiation processes within these lesions.