复合沸石止血剂放热和抗菌活性实验研究

Experimental study of exothermal and antibacterial activity of a compound zeolite hemostatic agent

目的:研发放热温度低并有抗菌活性的沸石止血剂。方法:用猪股动、静脉半横断出血模型,比较本室制备的Ag.Zn沸石和复合沸石与QC(Quikclot)的止血效果、放热、抗菌和血凝块强度。结果:QC止血效果好,但放热最高(75℃),组织有热损伤,无抗菌活性;复合沸石止血效果佳,放热显著降低,无热损伤,动物失血量和死亡率最低,有较强抗菌活性,血凝块强度大。结论:复合沸石止血高效,放热低并具有抗感染功能。

Objective：To research and develop a zeolite hemostatic agent with low exothermal temperature and antibacterial activity. Methods： The hemostatic efficiacy, exothermal temperature, tissue injury, antibacterial activity and clot strength of the Ag. Zn zeolite, the compound zeolite and the Quikclot （ Qc ） were compared in a swine model. The animal femoral artery and vein were semi -crosseuted to produce uncontrolled hemorrhage. Results： QC had a good hemostatic efficacy with some extent of thermal injury of tissue owing to the maximum exothermal temperature （75℃）, whereas in other groups the exothermal temperature was lower than 40℃ without any thermal injury. Conclusion： Compound zeolite possesses the characteristics of higher hemostatic efficacy, lower exothermal temperature and stronger antibacterial activity.