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抗肿瘤药Vorinostat的合成 被引量：7

Synthesis of Antitumor Agent Vorinostat
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摘要 以辛二酸为原料,通过连续两步混合酸酐法制得抗肿瘤药vorinostat,总收率约62%。 Vorinostat was synthesized from suberic acid by consecutive mixed anhydride method with an overall yield of about 62 %.
作者 焦杰 徐文方
机构地区 山东大学药学院药物化学研究所
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2009年第2期86-87,共2页 Chinese Journal of Pharmaceuticals
基金 国家科技部863专项研究课题(2007AA02Z314)
关键词 VORINOSTAT 抗肿瘤药 组蛋白脱乙酰酶抑制剂 合成 vorinostat antitumor agent histone deacetylase inhibitor synthesis
分类号 R979.19 [医药卫生—药品]
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参考文献7

  • 1Richon VM, Emiliani S, Verdin E, et al. A class of hybridpolar inducers of transformed cell differentiation inhibits histone deacetylases [J]. Proc Natl Acad Sci USA, 1998, 95 (6) : 3003-3007.
  • 2Mark PA. Discovery and development of SAHA as an anticancer agent [J]. Oncogene, 2007, 26 (9) : 1351-1356.
  • 3FDA Approves New Drug for Skin Cancer, Zolinza [EB/OL]. [2006-10-06]. http://www.fda.gov/bbs/topics/ news/2006/new01484.html.
  • 4Breslow R, Marks PA, Rifkind BA, et al. Novel potent inducers of terminal differentiation and methods of use thereof: WO, 9307148 [P]. 1993-04-15.
  • 5Stowell JC, Huot RI, van Voast L, et al. The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells [J]. J Med Chem, 1995, 38(9): 1411-1413.
  • 6Sbardella EG, Massa S. A new facile and expeditious synthesis of N-hydroxy-N'-phenyloctanediamide, a potent inducer of terminal cytodifferentiation [J]. OrgPrep Proced lnt, 2001, 33 (4) : 391-394.
  • 7Gediya LK, Chopra P, Purushottamachar P, et al. A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells [J]. J Med Chem, 2005, 48(15): 5047-5051.

同被引文献48

  • 1谢沐风.如何建立高效液相色谱法测定有关物质的方法[J].中国医药工业杂志,2007,38(1):45-48. 被引量：62
  • 2Sakajiri S,Kumagai T,Kawamata N,et al.Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines[J].Exp Hematol,2005,33(1):53-61.
  • 3Cohen LA,Marks PA,Rifkind RA,et al.Suberoylanilide hydroxamic acid (SAHA),a histone deacetylase inhibitor,suppresses the growth of carcinogen-induced mammary tumors[J].Anticancer Res,2002,22 (3):1497-1504.
  • 4Breslow R,Marks PA,Rifkind RA,et al.Novel potent inducers of terminal differentiation and methods of use thereof:WO,9307148[P].1993-04-15.(CA 1993,119:138765)
  • 5Stowell JC,Huot RI,Van Voast L.The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells[J].J Med Chem,1995,38(8):1411-1413.
  • 6Sbardella EG,Massa S.A new facile and expeditious synthesis of N-hydroxy-N'-phenyloctanediamide,a potent inducer of terminal cytodifferentiation[J].Org Prep Proced Int,2001,33 (4):391-394.
  • 7Gediya LK,Chopra P,Purushottamachar P,et al.A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells[J].J Med Chem,2005,48 (15):5047-5051.
  • 8FDA Approves.New Drug for Skin Cancer,Zolinza[EB/OL].http://www.fda.gov/bbs/topies/news/2006/new01484.htm1,2006-10-06.
  • 9Kelly WK,Marks PA.Drug insight:Histone deacetylase inhibitorsdevelopment of the new targeted anticancer agent suberoylanilide hydroxamic acid[J],Nat Clin Pract Onco1,2005.2(3):150-157.
  • 10Breslow R,Marks PA,Rifkind RA,et al.Novel potent inducers of terminal differentiation and methods of use thereof:WO,9307148[P].1993-04-15.

引证文献7

二级引证文献15

中国医药工业杂志
2009年 第2期

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