护肝宁片对卡马西平在大鼠体内药物动力学的影响

Effect of Huganning Tablets on Pharmacokinetics of Carbamazepine in Rats

探讨了护肝宁片对卡马西平在大鼠体内药物动力学的影响。大鼠随机分为生理盐水对照组和护肝宁片给药组。护肝宁片连续给药10d后,灌胃给予卡马西平(50mg/kg),用HPLC法测定卡马西平的血药浓度。采用非隔室模型分析方法计算卡马西平的药物动力学参数。单用卡马西平及与护肝宁片合用后,两组的Ke、t1/2、CL、cmax、tmax无显著性差异(P>0.05),而AUC则有显著性差异(P<0.05)。结果表明,口服护肝宁片可降低卡马西平的吸收,但不影响卡马西平的体内代谢。

The interaction between carbamazepine and Huganning tablets in rats was discussed. The reference and test group was administrated respectively with normal saline and Huganning tablets. After administrated with Huganning tablets for 10 d, carbamazepine was ig administrated to the rats. The plasma concentrations of carbamazepine were determined by HPLC. Non-compartmental model methodology was used for pharmacokinetic analyses. There was no significant difference between the two groups in the pharmacokinetic parameters of carbamazepine, such as Ke, t1/2, CL, cmax, tmax （P〉0.05）, except AUC （P〈0.05）. The result showed that Huganning tablets might decrease the absorption, but not affect the metabolism of carbamazepine in rats.