摘要
以乙腈-10mmol乙酸铵水溶液(7∶93)(加冰乙酸调至pH 4.0)为流动相,半制备高效液相色谱分离得到抗骨质疏松药雷奈酸锶中的一种杂质,测定了其UV、IR、MS及核磁共振全谱,并确定其结构为2-[双(羧甲基)氨基]-3-氰基-4-噻吩乙酸。
The impurity in strontium ranelate was obtained by semiprepatative high performance liquid chromatography with mobile phase of acetonitrile-10mmol ammonium acetate aqueous solution (7 : 93, pH 4.0), and the structure was identified to be 2-[bis (carboxymethyl)amino]-3-cyano-4-thiopheneacetic acid by UV, IR, MS in HNMR and CNMR.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2009年第2期133-134,145,共3页
Chinese Journal of Pharmaceuticals