雷奈酸锶中一种杂质的分离制备及结构确证

Separative Preparation and Structure Conf irmation of the Impurity in Strontium Ranelate

以乙腈-10mmol乙酸铵水溶液(7∶93)(加冰乙酸调至pH 4.0)为流动相,半制备高效液相色谱分离得到抗骨质疏松药雷奈酸锶中的一种杂质,测定了其UV、IR、MS及核磁共振全谱,并确定其结构为2-[双(羧甲基)氨基]-3-氰基-4-噻吩乙酸。

The impurity in strontium ranelate was obtained by semiprepatative high performance liquid chromatography with mobile phase of acetonitrile-10mmol ammonium acetate aqueous solution （7 ： 93, pH 4.0）, and the structure was identified to be 2-[bis （carboxymethyl）amino]-3-cyano-4-thiopheneacetic acid by UV, IR, MS in HNMR and CNMR.