α-生育酚油酸酯的合成及结构表征

Synthesis and structural characterization of α-tocopherol oleate

以α-生育酚和油酸为原料,三乙胺为催化剂,二氯甲烷为溶剂,氮气保护,催化剂用量5%(以α-生育酚计)、原料配比2.5∶1(油酸酰氯与α-生育酚的摩尔比)、反应温度45℃、反应时间5h,合成了α-生育酚油酸酯,经减压蒸馏产率达96%以上。运用紫外光谱、红外光谱、质谱、1H-NMR和13C-NMR表征了合成产物的结构。

The α - tocopherol oleate was synthesized with 96% yield from α - tocopherol and oleic acid with the triethylamine as the catalyst in dichloromethane solution under the following conditions ： molar ratio of oleic chloride to α- tocopherol 2.5：1, catalyst dosage 5 % （based on the mass of α- toeopherol） , reaction temperature 45 ℃ and reaction time 5 h. The structure of α - tocopherol oleate was characterized by UV, FT - IR, MS, ^1H - NMR and ^13 C - NMR.