EphA2与E—cadherin在大肠癌组织中的表达

Expression of EphA2 and E-cadherin in colorectal carcinoma

目的探讨EphA2和E—cadhefin在大肠癌组织中的表达及其临床意义。方法采用免疫组织化学S-P方法检测67例大肠癌和28例正常大肠黏膜组织中EphA2和E—cadherin的表达，并分析其与临床病理因素的关系。结果大肠癌组织中EphA2阳性和E-cadhefin阴性表达均显著高于正常大肠黏膜组织（P〈0．01）。EphA2阳性和E-cadhefin阴性表达与大肠癌分化程度、浸润深度和淋巴结转移差异有统计学意义（P〈0．01或P〈0．05），而与大肠癌大体类型差异无统计学意叉（P〉0．05）。EphA2与E-cadherin表达呈负相关（r=-0．45，P〈0．05）。结论EphA2与E—cadhefin异常表达可能共同参与大肠癌的发生、发展与转移，EphA2可与E-cadhefin结合作为判断大肠癌恶性程度和预后的指标。

Objectives To explore the expression and clinical significance of EphA2 and E-cadherin in colorectal carcinoma. Methods The expression of EphA2 and E-cadherin in 67 cases of colorectal carcinoma and 28 cases of normal large intestine tissues were determined by immunohistochemical method（S-P method）, and their relationship to clinicopathological characteristics were analyzed. Results The positive expression of EphA2 and negative expression of E-cadherin in colorectal carcinoma tissues were significantly higher than those in normal intestine tissues（ P 〈 0. 01 ）. The positive expression of EphA2 and negative expression of E-cadherin were positively correlated with tumor histological grade, invasive depth and lymph node metastasis （ P 〈0.01 or P 〈0.05）, but not correlated with tumor gross type（ P 〉 0. 05）. The expression of EphA2 was negatively related with E-cadherin. Conclusions The abnormal expression of EphA2 and E-cadherin may be together involved in the development and progression of colorectal carcinoma： It may be a good marker for monitoring the malignant degree and the prognosis of colorectal carcinoma by combining E-cadherin and EphA2.