清养透解法为主综合治疗81例系统性红斑狼疮临床疗效评价

Evaluation to the Clinical Curative Effect of the SLE Patients Treated by the Synthetical Project Main by Qingyangtoujie Method

目的:评价以伏气温病理论指导下运用清养透解法为主综合治疗81例系统性红斑狼疮(SLE)的临床疗效。方法:采用前瞻性、单盲随机对照方法,将118例临床常见证型(阴虚内热证、瘀热痹阻证、肝肾阴虚证)SLE患者按2:1比例分成治疗组(81例)和对照组(37例),治疗组给予清养透解法为主综合治疗方案,对照组给予西医常规治疗方案,治疗90天后评价其临床疗效。结果:①治疗后治疗组总体疗效高于对照组,有统计学差异(P<0.05)。②疗效性观测:两组在临床各症状均有不同程度的改善,且治疗组的症状消失率均高于对照组,动态显示治疗组在各个症状下降幅度较对照组大而平稳。③免疫指标比较:提示两组均能不同程度改善免疫学指标,无统计学差异(P>0.05)。动态观察治疗组具有更好的稳定性,波动幅度小。④激素剂量比较:两组所用激素剂量等级分布和剂量大小均有统计学差异(P<0.05),治疗组较对照组能更大幅度地降低激素使用剂量。⑤病情反复次数及并发症比较:治疗组均少于对照组,差异有统计学意义(P<0.05)。结论:以伏气温病理论指导下运用清养透解法为主综合治疗方案不仅总体疗效优于对照组,明显改善症状,且能明显减少激素用量及西药的毒副作用、减少复发次数。

Objective：To evaluate the clinical curative effect of the SLE patients treated by the synthetical project of qingyang toujie method under the theory of epidemic febrile diseases. Methods： According the methods of preceding, randomization,single blind and controlled method,we separate the 118 eligible patients into treatment group （81 cases）and contrast group（37 cases） according to ratio of 2： 1. Treatment group was adapted by the qingyangtoujie method synthetical project and contrast group was adapted by the routine west medicine project and we evaluate the clinical curative effect after 90 days. Results ：①Compare the total curative effect of two groups after treated, the curative effect of disease and symptom after intervention in treatment group are higher than contrast group, there is statistical significance （ P 〈 0. 05 ）. ②Observe curative effect ： two groups have improved in different degree in all symptoms, and the radio of symptom disappear in treatment group is higher than contrast one, there are statistical significance（ P 〈0. 05 ）. It indicated dynamic that the treatment group has more stability following the time than the contrast one. ③Compare immunity index ：it indicated that two kinds of treatment subjects have been improved in correlation immunity indices, there are no statistical significance（ P 〉0. 05 ）. It indicated dynamic that the treatment group has more stability and less fluctuation than contrast one. ④Compare the scale and size of hormone＇s dose：there are statistical significance after intervention （P 〈 0. 05 ）, treatment group has higher degree decrease than contrast group. ⑤Compare the times of disease repeating and syndrome ： the treatment group are less than contrast one after intervention, there is statistical significance （P 〈 0.05 ）. Conclusion：The total curative effect of treatment group treated by the synthetical project of qingyangtoujie method directed by the theory of Epidemic Febrile Disease is not only better than contrast group, but also more remarkable improve the clinical symptom, decrease the dose of hormone and side-effect,reduce repeating times.