相干光生物测量法在儿童眼球测量中应用

The application of partial coherence interferometry on the ocular biometry of children

目的探讨相干光生物测量法在儿童眼球生物测量中的重复性和准确性，评价该方法在儿童中的应用价值。方法用ZeissIOL—Master3．02相干光生物测量仪（PCI）、QMC5．03接触式A型超声生物测量仪（A超）和TopconKR-8800角膜曲率计分别测量小儿眼科门诊患者126例244只眼的眼球轴长（Ax）、前房深度（ACD）和角膜曲率（K值）。其中男51例，女75例，平均年龄（10．7±2．9）岁（3～16岁）。全部患者排除眼部器质性病变，检查静态屈光。结果PCI和A超测量的Ax的变异系数（COV）分别为0．67％和0．72％，PCI测量的Ax和ACD分别比A超测量值大（0．22±0．22）mm和（0．10±0．20）mm，差异均有统计学意义，P〈0．05。PCI与A超测量结果显著相关，相关系数分别为0．98（Ax）和0．64（ACD），P〈0．05。PCI与曲率计测量的K值相比，差别为0．04D，无统计学意义，P〉0．05。结论PCI测量儿童眼球生物参数稳定可靠，与A超的测量结果高度相关，可重复性高于A超。PCI测量的K值与曲率计测量结果无差异。PCI可以替代A超和曲率计，有望成为儿童眼球生物测量的常规方法。

Objective To evaluate the repeatability and accuracy of partial coherence interferometry on the ocular biometry of children by comparing it with ultrasonic biometry and auto-keratometry.Methods Zeiss IOL-Master3.02,QMC5.03 ultrasonic A-scan and Topcon KR-8800 auto-keratometry are used sequentially in a group of children which contains 126 cases （244 eyes）with average age （10.7 ± 2.9）years （3-16 years ）.Results The coefficient ofvariation（COV）ofPCI and A-scan on the measurement of Ax were 0.67% and 0.72% ,respectively.The Ax and ACD values were significantly larger with PCI （P 〈0.05）than with A-scan, with the differences of 0.22±0.22mm and 0.10±0.20mm, respectively.PCI is significantly correlated with A-scan on the measurement of Ax （r=0.98）and ACD （r=0.64）.The keratometric readings of PCI and auto-keratometry aren＇t significantly different （P 〉0.05）.Conclusiorts PCI is a useful method on the ocular biometry of children with repeatability higher than A-scan.PCI can be an alternative method on routine ocular biometry of children instead of A-scan and auto-keratometry.