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大鼠硬脂酰辅酶A去饱和酶1重组慢病毒载体的构建及其在293T细胞中的表达 被引量：2

Lentivirus-mediated expression of rat SCD1 gene in 293T cells
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摘要 硬脂酰辅酶A去饱和酶1（SCD1）是单不饱和脂肪酸（MUFA）生物合成限速酶，与细胞色素b5、细胞色素b5还原酶构成复合酶系共同催化硬脂酰辅酶A（18：0）和软脂酰辅酶A（16：0）等饱和脂肪酸形成油酰辅酶A（18：1）和棕榈油酰辅酶A（16：1）等单价不饱和脂肪酸。后者是体内合成甘油三酯、胆固醇酯和膜磷脂的底物，从而调节血清中低密度脂蛋白水平、脂质代谢、细胞膜流动性及抗氧化作用。
作者 蔡德丰 范建高 陆元善 刘兰 蔡小波
机构地区 上海交通大学附属第一人民医院检验科 脂肪肝诊治中心
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2009年第2期143-144,共2页 Chinese Journal of Hepatology
关键词 代谢综合征 硬脂酰辅酶A去饱和酶 大鼠 慢病毒载体 Metabolic syndrome Stearoy CoA desaturase Rat Lentivirus vector
分类号 R589 [医药卫生—内分泌]
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参考文献9

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二级参考文献6

共引文献6

同被引文献25

  • 1陆元善,范建高,方继伟,丁晓东,杨兆瑞.瘦素及硬脂酰CoA去饱和酶-1在高脂饮食大鼠非酒精性脂肪肝发病中的作用[J].世界华人消化杂志,2005,13(19):2327-2331. 被引量：9
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中华肝脏病杂志
2009年 第2期

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