冠心病合并代谢综合征者炎症因子水平与冠脉病变程度的研究

Relationship between inflammatory factors and severity of coronary artery stenosis in patients with coronary heart disease complicated by metabolism syndrome

目的:探讨炎症因子水平在冠心病合并代谢综合征诊断中的意义。方法:收集2004年12月到2006年6月在我院冠状动脉(冠脉)造影证实的连续冠心病患者448例,按有无代谢综合征分为代谢综合征组(241例)和非代谢综合征组(207例),测定血脂、白细胞(WBC)计数、超敏C反应蛋白(hs-CRP)水平,根据冠脉造影结果评价冠脉病变严重程度。结果:代谢综合征组血浆hs-CRP水平、WBC计数显著高于非代谢综合征组。与非代谢综合征组相比,代谢综合征组冠状动脉3支病变发生率高,总狭窄指数高,单支病变发生率低,差异具有统计学意义。结论:hs-CRP水平、WBC计数升高是冠心病合并代谢综合征的危险因素,炎症在疾病发生发展过程中起重要作用。

Objective To evaluate the significiance of serum level of inflammatory factors in patients with coronary heart disease complicated with metabolism syndrome. Methods From December 2004 to June 2006, 448 cases undergoing coronary angiography were proven to be coronary heart disease. They were divided into two groups according to with or without metabolism syndrome. WBC counts, and the serum level of lipidprotein, fasting glucose and high sensitive C-reactive protein （hs-CRP） were tested in the following morning of their hospitalization. The severity of coronary artery lesions was evaluated by coronary artery score. Results The serum level of hs-CRP and WBC count in patients with coronary heart disease complicated with metabolism syndrome was much higher than those without also coronary three-vessel lessions were more frequently identified and stenosis score was higher. Conclusion hs-CRP and WBC count may be the risk factors of the coronary heart disease patients with metabolism and inflammation is involved the whole process.