湛江地区有死胎史夫妇的α地贫1基因筛查

Gene screening for α-thalassemia 1 in the couples with stilibirth history in Zhanjiang area.

用两对引物进行聚合酶链反应（ＰＣＲ）扩增α珠蛋白基因，时湛江地区６０对有死胎史的夫妇进行了α地贫１的基因筛查，结果检出其中２３对夫妇双方均为α地贫１，占本组病例的３８．３％，另有２对夫妇其中一方为α地贫１，表明α地贫１纯合于即ＨｂＢａｒｔ＇ｓ是本地区死胎发生的主要原因，对死胎夫妇进行α地贫１的基因筛查是地贫高发区重要的优生措施。

Gene screening fot α-thalassemia 1 was per- formed in 60 couples with stillbirth history in Zhanjiang by polymerase chain reaction using 2 pairs of primers. The results showed that 23 (38.3%) of the 60 couples were detected as α-tha- lassemia 1 and 1 spouse as α-thalassemia 1 in an- other 2 couple., indicating that homuzygous o-tha- lassemia 1 (Hb Bart's) was the major cause of the stillbirth in Zhanjiang. Gene screening for α-tha- lassemia 1 in the couples with stillbirth history is an important measure for birth health in the areawhere thalassemia is common.