龙岩市1988～1999年出生人群A群C群流行性脑脊髓膜炎抗体水平调查

To Investigate Group A And C Cerebro-Spinal Meningitis Immune Body Level Of Crowd Born From 1988 To 1999 Year In Longyan City

目的了解龙岩市1988～1999年出生人群A群、C群流行性脑脊髓膜炎(流脑)抗体水平,以制定预防控制策略。方法2006年应用分层随机抽样,抽取部分1988～1999年出生健康人群血清,采用酶联免疫吸附试验(ELISA)方法进行了A群、C群流脑IgG抗体检测。结果A群流脑抗体阳性率平均为84.04%(1627/1936),各年龄组、各县(市、区)和既往计划免疫工作综合质量好、中、差类别乡镇的A群流脑抗体水平均有非常显著差异,提示我市预防接种工作发展不平衡,A群流脑疫苗加强免疫不够落实。C群流脑抗体阳性率平均为4.18%(81/1936),存在C群脑膜炎球菌的自然感染。结论龙岩市1988～1999年出生人群A群流脑已形成较好的免疫屏障,C群流脑无免疫力,建议开展A+C群流脑疫苗的接种工作。

Objective We understood group a and c cerebro-spinal meningitis immune body level of crowd born from 1988 to 1999 year, in order to formulate anticipatory control strategy. Methods We gathered part blood serum of healthy crowd born from 1988 to 1999 year through application lamination random sampling in 2006, examined IgG immune body of group a and c cerebro-spinal meningitis by ELISA method. Results Group a cerebro-spinal meningitis immune body masculine gender rate was equally 84.04% （1627/1936）, The difference between different age groups, various counties （city, area） and different category villages and towns according to EPI work synthesis quality was very remarkable. It prompted that EPI work development was not balanced in longyan city. The strengthen immunity of group a epidemic cerebrospinal meningitis vaccine did not carry out well. Group c epidemic cerebrospinal meningitis immune body masculine gender rate was equally 4.18% （81/1936）.There was nature infection of group c meningococcus. Conclusion Group a epidemic cerebrospinal meningitis had formed good immunity barrier of crowd born from 1988 to 1999 year in longyan city. The crowd had not immunity of group c epidemic cerebrospinal meningitis. We suggested to develop vaccination work of a＋c group epidemic cerebrospinal meningitis vaccine.