卡前列素配伍宫缩素防治前置胎盘产妇剖宫产术后出血的临床研究

Clinicl study of combination of hemabat with oxytocin on hemorrhage of cesarean section in placenta previa puerpera

目的观察卡前列素配伍宫缩素治疗前置胎盘产妇剖宫产术后出血的有效性和安全性。方法对69例前置胎盘的产妇行剖宫产。术中胎儿娩出后随机按宫缩剂使用情况分为两组,对照组32例,宫缩素20 U于宫体注射,另20 U加入液体中静脉滴注;实验组37例,宫缩素20 U于宫体注射,另将卡前列素1枚放入直肠中。并计算两组术后2 h出血量及总出血量,并观察两组的副反应。结果(1)两组产妇术后总出血量及2 h出血量分别为对照组(635±219)mL、(216±193)mL,实验组(432±219)mL、(118±115)mL,两组相比较,差异有统计学意义(P<0.01)。(2)两组产妇中,总出血量≥1000 mL共12例,其中对照组8例(66.7%),实验组4例(33.3%)。(3)副反应发生率对照组为6.25%(2/32),实验组为13.5%(5/37),两组以呕吐为常见,短时间内好转。结论卡前列素配伍宫缩素用于前置胎盘产妇的剖宫产术可明显减少术后出血量。

Objective: To observe the effect and safety of combination of hemabat with oxytocin on hemorrhage of cesarean sec-tion in placenta previa puerpera.Methods: Sixty-nine placenta previa women with cesarean section were divided into 2 groups,the control group(n=32) received 20 u oxytocin injected into uterus body plus 20 u oxytocin intervenous drop infusion;the ex-periment group(n=37) received 20 u oxytocin injected into uterus body plus rectal administration of hemabat,The bleeding vol-ume within 2 hour after cesarean section and the total hemorrhage volume were measured.The side effect of each group was observed.Results: The total hemorrhage volume of the control group(635±219mL),the bleeding volume within 2 hour(216± 193mL) significantly increased in the data of the experiment group(432±219mL and 118±115mL)(P < 0.01).The incidence of to-tal blood loss more than 1000mL in control group(66.7%),was higher than the experiment group(33.3%),the incidence of side effects in control group(6.25%) was less than experiment group(13.5%).Conclusion: Hemabat with oxytocin can significantly re-duce the amount of bleeding volume after cesarean section in pregnant women.