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Kiss-1在乳腺肿瘤中的表达及其临床意义 被引量：2

Expression and clinical significance of Kiss-1 in breast tumor
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摘要 目的探讨Kiss-1蛋白在乳腺肿瘤中的表达及其临床意义。方法用免疫组化技术检测100例乳腺癌、50例乳腺纤维腺瘤及瘤旁正常腺体Kiss-1蛋白的表达情况。结果乳腺癌及乳腺纤维腺瘤中Kiss-1的阳性率分别为60.0%(60/100)和36.0%(18/50),明显高于肿瘤周围正常腺体中阳性表达率29.0%(29/100)和14.0%(7/50,P<0.05)。Kiss-1在淋巴结阳性患者的表达率(43.6%)明显低于淋巴结阴性患者的表达率(70.5%,P=0.007)。结论Kiss-1蛋白的表达可能在抑制乳腺癌的淋巴结转移中起重要作用。 Objective To study the expression of Kiss-1 protein in breast tumor and its clinical significance. Methods The expression of Kiss-1 protein was examined by immunohistochemistry in 100 patients with breast cancer, 50 patients with fibroadenoma and their nearby normal breast tissues. Results Positive rates of Kiss-1 protein in breast cancer and breast fibroadenoma tissues were 60. 0% （60/100） and 36.0% （ 18/50）, significantly higher than 29.0% （29/100） and 14.0% （7/50） positive rates in their nearby normal tissues respectively（ P 〈 0. 05 ）. Kiss-1 positive rate was 43. 6% in breast cancer patients with lymph node metastasis, markedly lower than 70. 5% positive rate in patients without lymph node metastasis （P = 0. 007 ）. Conclusions The expression of Kiss-1 protein may play an important role in suppressing lymph nodes metastasis of breast cancer.
作者 周波 谢菲 郭嘉嘉 杨德启
机构地区 北京大学人民医院乳腺外科
出处 《中国肿瘤临床与康复》 2009年第1期7-9,共3页 Chinese Journal of Clinical Oncology and Rehabilitation
关键词 KISS-1 乳腺肿瘤 转移 Kiss-1 Breast neoplasms Metastasis
分类号 R737.9 [医药卫生—肿瘤] R730.45 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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二级参考文献16

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共引文献12

同被引文献19

  • 1江忠清,曲军英,朱凤川,郑秀,张声,游彩玲.宫颈癌组织中MMP-9和CD44V6表达与癌细胞增殖及侵袭转移的关系[J].中华肿瘤防治杂志,2006,13(15):1166-1170. 被引量：3
  • 2吴阶平.顾方六.郭应禄,等.吴阶平泌尿外科学[M].4版.济南:山东科学技术出版社,2009:889-918.
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中国肿瘤临床与康复
2009年 第1期

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