幽门螺杆菌感染与大肠癌关系的Meta分析

Meta - analysis on the relationship between colorectal cancer and Helicobacter pylori infection

目的应用Meta分析方法对国内外已发表的有关幽门螺杆菌（Hp）感染与大肠癌（包括结直肠腺瘤）关系的研究进行综合评价。方法对符合纳入标准的14篇文献用Review manager4.2软件进行Meta分析，计算比值比（OR）、95％可信区间（95％CI）并做出几何漏斗图。结果纳入总样本量为3165例，其中病例组为1330例，对照组为1835例；Meta分析合并OR=1.36，95％CI：1.01-1.82。儿何的漏斗图形虽不对称，但经敏感性分析和失效安全数分析结果显示，发表偏倚对研究结果影响较小。结论Hp感染可导致大肠癌发生的危险性增加。

Objective Analyzing all the related studies that have been published in the world to evaluate the relationship between colorectal cancer （including colorectal adenomas） and Helicobacter priori infection by means of Meta-analysis. Methods To analyze the 14 references consistent with inclusion criteria by reviewing manager 4.2, calculating the odds ratio and 95% confidence interval, then drawing funnel plot. Results The total sample size is 3165, cases and controls are 1330 and 1835, respectively. The pooled OR is 1.36, and 95% confidence interval 1.01, 1.82. The graphical funnel plot appearing asymmetrical, but analyzing by sensitivity analysis and fail-safe number calculation. The results are affected by publication bias. Conclusion The results of our Meta-analysis show that Helicobacterpflori infection is a possible risk of colorectal cancer.