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调节性T细胞在防治移植物抗宿主病中作用的研究进展

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摘要 移植物抗宿主病(GVHD)始终是导致异基因造血干细胞移植(HSCT)失败和死亡的主要原闲之一,而移植物中的异基因反应性T细胞则是GVHD发生的关键。然而反应性T细胞的缺失又会严重影响造血干细胞的植入以及移植物抗自血病(GVL)效应。近几年的研究表明,调节性T细胞(Regulatory Tcells,Tregs)在诱导和维持移植免疫耐受中发挥极为重要的作用,尤其是还能够保留一定的GVL效应。
作者 骆媛 奚永志
出处 《中华血液学杂志》 CAS CSCD 北大核心 2009年第2期141-144,共4页 Chinese Journal of Hematology
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