摘要
The hypothesis postulating that Mycobacterium avium paratuberculosis(MAP) is the cause of Crohn's disease(CD) has been circulating for many years.Advances in molecular techniques,such as polymerase chain reaction and culture methods,have enabled researchers to demonstrate that there is an association between MAP and CD.Recently,genome-wide association studies have identified novel susceptibility genes for CD,which are critical for generation of an adaptive immune response that is protective against intracellular pathogens,including M.tuberculosis infection.However,the role of MAP as a cause of CD suffered a setback with the report that administration of antimycobacterial therapy failed to lead to a sustained response in CD patients.Accordingly,this review sought neither to confirm nor refute this,but instead to survey recent literature on the role of MAP in CD.
The hypothesis postulating that Mycobacterium avium paratuberculosis （MAP） is the cause of Crohn＇s disease （CD） has been circulating for many years. Advances in molecular techniques, such as polymerase chain reac- tion and culture methods, have enabled researchers to demonstrate that there is an association between MAP and CD. Recently, genome-wide association studies have identified novel susceptibility genes for CD, which are critical for generation of an adaptive immune re- sponse that is protective against intracellular patho- gens, including M. tuberculosis infection. However, the role of MAP as a cause of CD suffered a setback with the report that administration of antimycobacte- rial therapy failed to lead to a sustained response in CD patients. Accordingly, this review sought neither to confirm nor refute this, but instead to survey recent literature on the role of MAP in CD.
基金
Supported by Grant from Fundación de Investigación MédicaMutua Madrileía (Professor M Díaz-Rubio)
关键词
肺结核传染病
治疗
临床
疗效
Mycobacterium avium subspecies paratuber-culosis
Crohn＇s diasease
Inflammatory bowel disease
