摘要
采用一组特异性抗膀胱癌单克隆抗体MAb(T16、M344、T138、T43),以APAAP免疫细胞化学方法,对63例膀胱移行细胞癌及10例非肿瘤患者的膀胱冲洗液作了研究。T16在全部63份标本呈阳性。随着肿瘤分期、分级的升高,M344阳性率逐渐降低,T138及T43阳性率逐渐升高。此三种MAb与肿瘤复发也有一定的对应关系。尿细胞学与MAb联合应用,可弥补相互间的不足,使肿瘤检出率进一步提高。结果表明:M344、T138及T43MAb的阳性表达与肿瘤的分期、分级及预后密切相关,可作为膀胱肿瘤恶性程度、复发及早期诊断的估价指标。
Using a panel of four monoclonal antibodies(T16,M344,T138,T43),an mmunocyTochemical(APAAP)study of bladder washings was carried out in 63 cases of transitional Cell carcinoma and 10 of non-tumor patients.The results indicates that the positivity of M344,T138 and T43 was closely related with stage,grade and prognosis.It can be used as Evaluating marker of malignant dergee,recurrence and early diagnosis.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1998年第2期109-110,共2页
Cancer Research on Prevention and Treatment
关键词
膀胱肿瘤
单克隆抗体
特异性
免疫细胞化学
<Keywrods>transitional carcinoma of bladder
monoclonal antibody
immunocytochemistry
urine cytology