表皮生长因子增强二甲基肼诱发大白鼠大肠癌的效力

Epidermal growth factor enhanced the effect of DMH induce colorectal cancer in wistar rat

本文应用动物诱癌试验观察内源性和外源性表皮生长因子（EGF）对二甲基肼（DMH）诱发WISTAR鼠大肠癌效力的影响。将60只大白鼠随机分咸四组：高EGF组、普通组（对照组）、低EGF组、单EGF组、用DMH连续诱癌20周。结果发现高EGF组动物诱癌阳性率、平均负瘤数、肿瘤平均体积均明显高于普通组，更高于低EGF组（P＜0．05），单EGF组无肿瘤产生。提示EGF可增强DMH诱发WISTRR鼠大肠癌的效力，但不能独立致癌，在本实验中EGF有类似促癌剂的作用。

We research the effect of epidermal growth factor(EGF)to 1, 2-dimethylhydrazine (DMH) induce colorectal cancer in wistar rat by animal mutagenic expertment. 60 cases wistar rat divided into 4 groups randomazationly, High EGF+DMH; nature EGF+DMH;low EGF+DMH;single EGF(lug/kg. day), DMH 20mg/week. kg body weight. So. 20weeks continnuiusly. No cancer reveal in 10 weeks;about half of rat produced cancer in 15weeks;there are 67-100% rat reveal colorectal cancer in 20weeks,no rat reveal cancer in single EGF group. The positive rate of cancer,number of cancer in each rat,average volume of every cancer in high EGF group were higher than these in nature EGF group or low EGF group significently(P<0.05).This results suggest that:EGF was not a essential factor in the progress,but EGF can enhance the mutagenesis effect of DMH induced colorectal cancer in wistar. EGF was not a carcinogen,but. a promoter of carcinogen in this expertment.