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组织因子途径抑制物的临床研究进展 被引量:4

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摘要 组织因子途径抑制物(tissue factor pathway inhibjtor,TFPI)是组织因子诱导的凝血过程的负性调节物之一。TFPI主要由微血管内皮细胞合成,可直接抑制因子Xa,并与因子Xa结合反馈抑制因子Ⅶa/组织因子复合物。在许多疾病诸如播散性血管内凝血(DIC)、缺血性心脏病、糖尿病、肝肾功能衰竭、晚期癌症等皆有升高,并在一定程度上与疾病的严重程度与预后相关。此外,随着重组TFPI的成功制备、动物实验的肯定结果及研究工作的不断完善,其在DIC、抗凝。
作者 赵维莅
出处 《国外医学(输血及血液学分册)》 1998年第2期87-91,共5页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
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