非类固醇抗炎药与幽门螺杆菌相互作用诱发消化性溃疡出血的研究

The Relationship between Non-steroidal Anti-inflammatory Drugs And Helicobacter Pylori in Patients with Peptic Ulcer Bleeding

为了评估非类固醇抗炎药（ＮＳＡＩＤｓ）和幽门螺旋杆菌（Ｈｐ）在消化性溃疡病出血中的相互作用，对１０６例溃疡病出血患者进行了临床观察、Ｈｐ检测和病理学研究。结果表明，４１例（３８７％）溃疡病出血前有ＮＳＡＩＤｓ用药史，其中３６例Ｈｐ阳性，６５例（６１３％）无ＮＳＡＩＤｓ用药史，其中４２例Ｈｐ阳性，两者比较显示使用ＮＳＡＩＤｓ者的Ｈｐ阳性率较高（Ｐ＜００１）。组织学方面，Ｈｐ阳性的ＮＳＡＩＤｓ用药者主要表现为严重的慢性活动性胃炎，并常见胃粘膜局灶性坏死和微小糜烂形成，与Ｈｐ阳性的非ＮＳＡＩＤｓ用药者和Ｈｐ阴性的ＮＳＡＩＤｓ用药者比较，其胃粘膜受损更加严重。结果表明Ｈｐ感染者服用ＮＳＡＩＤｓ。

o evaluate the relationship between non-steroidal anti-inflammatory drugs(NSAIDs) and Helicobacter pylori(Hp) in patients with peptic ulcer bleeding,106 patients with peptic ulcer bleeding were observed and analyzed according to the clinical characteristics,Hp status and histopathologic examination. The results showed that 41(38.7%) of the 106 patients had definite history of NSAIDs use before the peptic ulcer bleeding,36 cases of them were Hp positive.The positivity rate of Hp was significantly higher than that in patients with no such drug use history(P<001).In aspect of histological changes,the Hp associated chronic gastritis would become more svere,if they took NSAIDs.The main lesions were mucosal necrosis,erosion and bleeding. Based on the above results,It is concluded that Hp infection increases the risk of peptic ulcer bleeding in patients who took NSAIDs。